![]() ![]() ![]() Notre postulat de base est un mimétique du développement de la microélectronique. Cette thèse essaie de donner une réponse au développement industriel des laboratoires sur puce. Cependant, les développements industriels à grande échelle des laboratoires sur puces restent encore à découvrir et à être exploités. Pour répondre à cette demande, des outils d’analyses miniaturisés, appelés « laboratoires sur puces » se sont développés en particulier sur le plan technique au cours de la dernière décennie. As result, we proved that DLP printing is not only a suitable method to develop microfluidic devices, but if correctly optimized it can also reproduce small features in the order of tens of micrometers rapidly.ĭepuis les années 2000 la demande en outils d’analyses biologiques et chimiques, fiables et portatifs a augmenté dans plusieurs domaines (santé, environnement, agroalimentaire, …). Finally, a proof-of-concept microfluidic device was fabricated, sealed to a PDMS membrane through an oxygen plasma treatment, and tested against leakage on a microfluidic circuit for one week. We proved that this optimization was beneficial also in terms of transparency (evaluated by UV-Vis spectrophotometry), and mechanical strength (evaluated by a compression test) of the printed resin. ![]() DoE method allowed us to have a deep understanding of the process without the need of any physical inspection of the involved phenomena, and to generate empirical models, correlating the process factors to the dimensions of the final printed object. Studying the process factors by a statistical methodology called Design of Experiment (DoE), we were able to achieve small features with high aspect ratio (60). In this study, we propose as alternative the production of devices by digital light processing (DLP), a vat photopolymerization technology, in combination with a commercially available, biocompatible resin. While this technique offers the possibility to produce features with high resolution, it is not flexible enough to respond to the necessity of customization and prototyping. They are traditionally produced by soft lithography: starting from a mold fabricated by optical photolithography, a Polydimethylsiloxane (PDMS) device is obtained by casting and baking. Organ-on-chip and Lab-on-chip are microfluidic devices widely applied in the biomedical field. Finally, the current open research issues of this technology along with the possible future research scope in the biomedical area have been presented. The biomedical applications of LoC in different fields like in diagnostics, cellomics, in environmental studies to control the effect of pathogens, to check the food quality such as for the detection of various antibiotic families in raw milk have also been discussed. Ongoing worldwide research projects based on LoC technology have been investigated and various constraints that need to be fulfilled for designing a LoC system are presented. This paper gives the detailed description of Lab-on-Chip technology including its system components. Due to the miniaturization of these biochemical operations, better diagnostic speed, cost efficiency, ergonomy, sensitivity and so on can be achieved. Lab-on-Chip (LoC) integrates various analyses such as biochemical operations, chemical synthesis, DNA sequencing onto a single chip which otherwise would have been performed in laboratory taking sufficient amount of time. ![]()
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